Work

A Hexanuclear Gallium(III) Complex with a {GaIII6(μ‐OH)10} Core Supported by Two Naphthalenediolate‐Based Ligands

Year: 2024

Type: article

Abstract: We have developed a family of 2,7‐disubstituted 1,8‐naphthalenediol ligands to pre‐organize two metal ions to the distance of two neighboring phosphate diesters of 6–7 Å in the DNA backbone by a rigid backbone. As complexes with divalent ions (CuII and NiII) bind to DNA, interferes DNA synthesis via PCR, and kills human cancer cells more efficiently than human stem cells of the same proliferation rate, we intended to increase the binding affinity by going from divalent to trivalent ions‐especially FeIII. Here, we apply GaIII as redox inactive model for FeIII and obtain for the first time a complex with trivalent ions. However, the structural characterization provides not a dinuclear GaIII complex, but a hexanuclear GaIII complex with a central {GaIII6(μ‐OH)10} core, that is yet unprecedented.

Source: Zeitschrift für anorganische und allgemeine Chemie

DOI: 10.1002/zaac.202400166

Authors: Maximilian Böhm, Anja Stammler, Jan Oldengott, Thorsten Glaser

Institution: Bielefeld University

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,840

Funder: Universität Bielefeld