Work

Regioselective Intermolecular Hydroamidation of β‐CF3‐1,3‐Enynamides: An Approach to Tri‐Substituted γ‐CF3‐Allenamides

Year: 2024

Type: article

Abstract: A simple base mediated, highly regioselective 1,4‐hydroamidation of β‐CF3‐1,3‐enynamides with secondary amides for synthesis of tri‐substituted γ‐CF3‐allenamides compounds was developed. N‐alkyl sulfonamides are generally good candidates for the present transformation. γ‐CF3‐allenamides could be employed for synthesis of potential value‐added compounds such as fluorinated halogenated pyrrole, tetrahydroquinoline and 2‐CF3‐putrescine derivatives.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202400674

Authors: Yuxuan Cao, Zongxiang Yu, Yizhen Chen, Lu Liu, Yuanjing Xiao

Institution: East China Normal University

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality

Awards: G6451139355, G7426111228