Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
Year: 2024
Type: article
Abstract: BACKGROUND: Increasing evidence supports the role of advanced glycation end products (AGEs) in atherosclerosis in both diabetic and non-diabetic patients, suggesting that therapeutic strategies targeting AGEs may offer potential benefits in this population. The Mediterranean diet is associated with improved biomarkers and anthropometric measurements related with atherosclerosis in addition to its ability to modulate AGE metabolism. Our aim was to determine whether the reduction in atherosclerosis progression (measured by changes in intima-media thickness of both common carotid arteries (IMT-CC)), observed after consumption of a Mediterranean diet compared to a low-fat diet, is associated with a modulation of circulating AGE levels in patients with coronary heart disease (CHD). METHODS: 1002 CHD patients were divided in: (1) Non-increased IMT-CC patients, whose IMT-CC was reduced or not changed after dietary intervention and (2) Increased IMT-CC patients, whose IMT-CC was increased after dietary intervention. Serum AGE levels (methylglyoxal-MG and Nε-Carboxymethyllysine-CML) and parameters related to AGE metabolism (AGER1 and GloxI mRNA and sRAGE levels) and reduced glutathione (GSH) levels were measured before and after 5-years of dietary intervention. RESULTS: The Mediterranean diet did not affect MG levels, whereas the low-fat diet significantly increased them compared to baseline (p = 0.029), leading to lower MG levels following the Mediterranean diet than the low-fat diet (p < 0.001). The Mediterranean diet, but not the low-fat diet, produced an upregulation of AGE metabolism, with increased AGER1 and GloxI gene expression as well as increased GSH and sRAGE levels in Non-increased IMT-CC patients (all p < 0.05). Although the Mediterranean diet increased MG levels in Increased IMT-CC patients, this increment was lower compared to the low-fat diet (all p < 0.05). CONCLUSIONS: Our results suggest that an improvement in modulation of AGE metabolism, which facilitates better management of circulating AGE levels, may be one of the mechanisms through which the Mediterranean diet, compared to a low-fat diet, reduces the progression of atherosclerosis in patients with CHD. Trial registration https://clinicaltrials.gov/ct2/show/NCT00924937 , Clinicaltrials.gov number, NCT00924937.
Source: Cardiovascular Diabetology
Institutions: Instituto de Salud Carlos III, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, University of Córdoba, Icahn School of Medicine at Mount Sinai, Consejo Superior de Investigaciones Científicas, Instituto de la Grasa
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,990
Funders: European Association of Social Psychology, Fundación Patrimonio Comunal Olivarero, European Commission, Ministerio de Ciencia e Innovación, Consejería de Salud y Familias, Junta de Andalucía, Junta de Andalucía, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Servicio Andaluz de Salud, Instituto de Salud Carlos III, Agencia Estatal de Investigación
Awards: G1188822794, G1198795973, G1221729352, G1337874456, G1855990336, G2262748287, G2634675147, G2647865469, G2774381085, G3303869175, G3315890543, G3381356214, G3480869486, G3518538256, G3681454997, G3690828678, G3750212409, G3898160223, G4042783231, G4221116905, G425668148, G4470375709, G4811896995, G5171014064, G5421974903, G5513598905, G5865727689, G589296787, G6193964292, G6312668090, Influencia de la obesidad en la evolución de la nefropatía diabética. Consumo de dos modelos de dieta cardiosaludables como estrategia terapéutica en el desarrollo de la enfermedad, G6594241516, Efecto del consumo de dos dietas saludables sobre el metabolismo de los productos finales de glicación avanzada y su influencia en el riesgo de arteriopatía periférica en pacientes con enfermedad coronaria, G8352492595, G8684520763
OpenAlex ID: W4403395707