Work

Formal Transformation of Benzylic Carboxylic Acids to Phenols

Year: 2024

Type: article

Abstract: Phenols play a crucial role as core structural motifs in natural products and also serve as fundamental building blocks in synthetic chemistry. Apart from the known protocols for the conversion of aryl precursors to phenols (i. e., decarboxylative oxygenation), we report here the efficient synthesis of phenols from the stable and readily available benzylic carboxylic acids under mild reaction conditions. The photocatalytic conversion of carboxylic acids to peroxides is a crucial step in this strategy, allowing the subsequent C-O bond formation via Hock rearrangement.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202403301

Authors: Chenhao Lou, Qiuwei Huang, Leiyang Lv, Zhiping Li

Institutions: Renmin University of China, Pingdingshan University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Innovative Research Group Project of the National Natural Science Foundation of China, National Natural Science Foundation of China, Renmin University of China, Fundamental Research Funds for the Central Universities

Awards: G2997328849, G4035047900, G4348272252, G8459744033