Work

Flower-Shaped Plasma Cells in Multiple Myeloma with Morphological Heterogeneity

Year: 2024

Type: article

Abstract: BACKGROUND: Flower-shaped nuclei in plasma cells are rare in multiple myeloma. CASE PRESENTATION: We report on an 88-year-old male who presented with a mass lesion in the clavicular region. A biopsy of the mass revealed an increase in mature plasma cells with round nuclei. In contrast, a bone marrow examination showed increased plasma cells with flower-shaped nuclei. The patient tested negative for human T-lymphotropic virus type-1 and was diagnosed with multiple myeloma. CONCLUSIONS: While multiple myeloma is known for intra-tumor heterogeneity, reports of morphological heterogeneity based on the site of tumor sampling are limited. In this case, the presence of plasma cells with flower-shaped nuclei enabled the identification of site-dependent morphological tumor heterogeneity.

Source: Diagnostics

DOI: 10.3390/diagnostics14202285