Correlations Between Oxidative Stress Markers and Coronary Anatomy in Percutaneously Treated Patients With Acute ST-elevation Myocardial Infarction
Year: 2024
Type: article
Study design: Observational Study
Abstract: Understanding biochemical mechanisms involved in acute myocardial infarction is crucial for future treatments. The current study analyzed the oxidative stress markers in patients with percutaneously treated acute ST-elevation myocardial infarction and correlated the findings to coronary anatomy and Syntax II score (SS-II). Blood samples were obtained before coronary re-perfusion, after one and 24 hours. The following markers of oxidative stress were determined: malondialdehyde (MDA), reduced glutathione to oxidized glutathione ratio (GSH/GSSG) and total antioxidant capacity (TAC). Thirty-seven consecutive patients were included. The patients were divided into groups according to the infarct-related artery: left anterior descending artery (LAD- group) vs non-LAD group, and according to the calculated SS-II, SS-II≤ 34 vs. SS-II>34. MDA concentration and GSH/GSSG ratio showed non-significant differences between LAD vs non-LAD groups at all time frames. Patients with LAD as the infarct-related artery had a significantly lower TAC 24 hours after re-perfusion: 30.22 ± 9.78 % inhibition in the LAD group vs. 35.7 ± 5.78 % inhibition in the non-LAD group, p=0.013. The oxidative stress markers were similar between patients regardless of the SS-II value, and neither the culprit vessel nor the SS-II significantly influenced the dynamics of oxidative stress markers.
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403401925