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A new bicyclo [3.3.1]nonadienemethanol-type lignan from the leaves of Taxus wallichiana Zucc.

Year: 2024

Type: article

Abstract: Following an α-glucosidase inhibitory activity-guided phytochemical study, a rare new bicyclo[3.3.1]nonadienemethanol-type lignan named 9,9′-oxidolanceolatanin B (1) and four known lignans, lanceolatanin B (2), pinoresinol (3), syringaresinol (4), and medioresinol (5), were isolated from a CHCl3-soluble fraction of Taxus wallichiana Zucc. leaves. The absolute configuration of 9,9′-oxidolanceolatanin B was elucidated based on NMR spectroscopic interpretation and ECD data. All isolated compounds 1–5 showed stronger α-glucosidase inhibitory potency than the positive control, acarbose. This data could support the conceit that Taxus wallichiana leaves could be a promising source for plant-based anti-diabetic drug discovery.

Source: Natural Product Research

DOI: 10.1080/14786419.2024.2414407

Authors: Phu Hoang Dang, Tu Hoai Tran, Tho Huu Le, Mai Thanh Thi Nguyen, Nhan Trung Nguyen

Institutions: Vietnam National University Ho Chi Minh City, Vietnam National University, Hanoi, Ho Chi Minh City University of Science

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4403405993

FWCI:

Cites: 25

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Related to: 10