Preoperative stroke predicts new postoperative clinically significant stroke in patients undergoing surgery for left-sided infective endocarditis
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective Operative timing remains controversial for patients with left-sided infective endocarditis (LSIE) with preoperative stroke (PREOS). Operative guidelines are determined on the basis of postoperative radiologically confirmed strokes (RCS). We evaluated the impact of PREOS on surgical outcomes. Methods Over 15 years, 331 patients underwent valvular surgery for LSIE at our center. PREOS (n = 71, 21%) and non-PREOS (n = 260, 79%) cohorts were identified. Propensity score matching was performed. Logistic regression identified risk factors for postoperative clinical stroke (PCS, defined as any new postoperative neurologic deficit), RCS and mortality. Results Among patients with PREOS, 24 of 71 (34%) had a hemorrhagic component, 34 of 71 (48%) were within 2 weeks of surgery, 46 of 71 (65%) experienced residual deficits, and 2 of 71 (3%) experienced hemorrhagic conversion postoperatively. Operative mortality was 24 of 331 (7%) and did not significantly differ between groups ( P = .083). Patients with PREOS had a greater incidence of PCS ( P = .001), repeat imaging of the head ( P < .001), new renal failure ( P = .006), and nonhome discharges ( P < .001). Propensity score matching upheld these trends. Logistic regression identified PREOS as a risk factor for PCS (odds ratio [OR], 8.76; P < .001). Intraoperative abscess (OR, 4.83; P = .013), cardiogenic shock (OR 8.51; P = .023), and tricuspid procedures (OR 5.03; P = .02) were RCS risk factors. PREOS (OR 3.12; P = .025), preoperative renal failure (OR 2.67; P = .043), immunosuppression (OR 7.09; P = .022), tricuspid regurgitation (OR 4.36; P = .011), and aortic valve procedures (OR 4.38; P = .033) were risk factors for mortality. Conclusions Among patients with LSIE undergoing surgery, PREOS is a risk factor for PCS and new renal failure. Patients with PREOS may require greater level of care upon discharge and may benefit from more stringent preoperative evaluation.
Source: JTCVS Open
Institution: University of Southern California
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,431
OpenAlex ID: W4403411448