Work

Combination therapy of bevacizumab and galunisertib extends TVN time window

Year: 2024

Type: article

Abstract: Tumor vascular normalization (TVN) enhances tumor perfusion and reduces metastasis, making it a promising alternative strategy for anti-angiogenic cancer treatment.1 The vascular endothelial growth factor (VEGF) family, known for its significant pro-angiogenic activity and anti-apoptotic effects on endothelial cells, consists of several members, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, PlGF, and EG-VEGF.2 Transforming growth factor β (TGF-β) regulates angiogenesis, acting as a pro-angiogenic factor at low concentrations and an anti-angiogenic factor at high concentrations.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2024.200888

Author: Ling Yin

Institution: University of Florida

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900