Work

UPLC-MS/MS analysis of axitinib and pharmacokinetic application in beagle dogs

Year: 2024

Type: article

Abstract: Objective: To develop a method for determining the concentration of axitinib in beagle dog plasma and utilize this method to investigate the pharmacokinetics of orally administered axitinib in beagle dogs. Methods: 399.3 → 282.96, respectively. Six beagle dogs were administered 0.33 mg/kg of axitinib orally, and venous blood samples were collected at 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 h post-dose for pharmacokinetic analysis. Results: ) of 97.13 ng h/mL for axitinib. Conclusions: The UPLC-MS/MS method developed in this study offers high specificity, rapid analysis, high recovery, excellent linearity, and minimal plasma volume requirements, making it well-suited for pharmacokinetic and drug interaction studies in beagles dogs.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e39422

Authors: Hengyu Bi, Yixin Wang, Xiaochen Ding, Jiahang Li, He Qi, Xiangjun Qiu

Institution: Henan University of Science and Technology

Language: English

Topic: Analytical Methods in Pharmaceuticals

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100