Work

Examining the causal genetic effects of substance use on aging

Year: 2024

Type: preprint

Study design: Observational Study

Abstract: Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, and opioid use and use disorders with indices of aging across the lifespan. There was evidence of tobacco and alcohol use and use disorders causally impacting physical, cognitive, and biological aging, with the effects of alcohol being more dependent on quantity of consumption; evidence of reverse causality was scant.

Source: medRxiv

DOI: 10.1101/2024.10.14.24315472

Authors: Jared V. Balbona, Paul Jeffries, Aaron J. Gorelik, Elliot C. Nelson, Ryan Bogdan, Arpana Agrawal, Emma C. Johnson

Institution: Washington University in St. Louis

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Awards: 7/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact, Biomedical Research Training in Drug Abuse, Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics data

OpenAlex ID: W4403417271

Cites: 11

Cited by: 1

Related to: 10