Work

Changes in reactive oxygen species and autofluorescence under hypoxia at the hippocampal CA3 area: Role of calcium and zinc influxes

Year: 2024

Type: article

Abstract: ) showed a more pronounced rise. KCl-induced depolarization significantly enhanced ROS formation, particularly under severe hypoxia. Inhibition of NMDA receptors reduced ROS generation without affecting autofluorescence, while chelation of zinc ions decreased ROS production and increased flavin adenine dinucleotide (FAD) autofluorescence. These findings suggest that, in hypoxic conditions, ROS formation is mediated by calcium entry through NMDA receptors and also by zinc influxes. Thus, these ions play a crucial role in oxidative stress, which may be related with neurodegenerative diseases associated with ROS dysregulation.

Source: Neurochemistry International

DOI: 10.1016/j.neuint.2024.105882

Authors: João L. Alves, Patrícia M. Reis, Rosa M. Quinta-Ferreira, M. Emília Quinta-Ferreira, Carlos M. Matias

Institutions: Centro de Neurociências e Biologia Celular, University of Coimbra, Chemical Engineering and Renewable Resources for Sustainability, University of Trás-os-Montes and Alto Douro

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,580