Sestrin2 serves as a scaffold protein to maintain cardiac energy and metabolic homeostasis during pathological stress
Year: 2024
Type: review
Abstract: Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide. Metabolic imbalances and pathological stress often contribute to increased mortality. Sestrin2 (Sesn2) is a stress-inducible protein crucial in maintaining cardiac energy and metabolic homeostasis under pathological conditions. Sesn2 is upregulated in response to various stressors, including oxidative stress, hypoxia, and energy depletion, and mediates multiple cellular pathways to enhance antioxidant defenses, promote autophagy, and inhibit inflammation. This review explores the mechanisms through which Sesn2 regulates these pathways, focusing on the AMPK-mTORC1, Sesn2-Nrf2, and HIF1α-Sesn2 pathways, among others. We can identify the potential therapeutic targets for treating CVDs and related metabolic disorders by comprehending these complex mechanisms. Sesn2's unique ability to respond thoroughly to metabolic challenges, oxidative stress, and inflammation makes it a promising prospect for enhancing cardiac health and resilience against pathological stress.
Source: The FASEB Journal
Authors: Blaise Seale, Lily Slotabec, Jennie D. Nguyen, Hao Wang, Cory Patterson, Fernanda Filho, Nadiyeh Rouhi, Michael I. Adenawoola, Ji Li
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
Awards: G18396362, Wyoming IDeA Networks of Biomedical Research Excellence, Activated Protein C Signaling in Aging, MIF and Cardiovascular Inflammation, G3736190297, G3942737795, G6769252780, Cardiorenal and Metabolic Diseases Research Center, G7792392266, Metformin Therapy for Ischemic Insult and Reperfusion Injury in Aging, Cardiorenal and Metabolic Diseases Research Center
OpenAlex ID: W4403431796