Development and evaluation of mucoadhesive buccal films for the sustained release of diclofenac sodium: An innovative approach for pain management
Year: 2024
Type: article
Abstract: The research explores the development and evaluation of mucoadhesive buccal films for the sustained release of diclofenac sodium, a widely used non-steroidal anti-inflammatory drug (NSAID) for pain relief. Mucoadhesive buccal films are an innovative drug delivery system designed to adhere to the mucous membrane in the oral cavity, enabling the controlled release of drugs directly into the bloodstream, bypassing first-pass metabolism and improving therapeutic outcomes. These films provide sustained release, localized action, and improved compliance, making them more convenient for patients. Mucus membranes, which are moist surfaces lining body cavities, are the main components of mucus gels. The wetting theory applies to mucoadhesion, which involves the release of mucus from the mucosal surface into the bloodstream. The study aims to develop a more efficient and effective method for the controlled release of diclofenac sodium, a potent anti-inflammatory and analgesic drug.
Authors: Mubasshera Sabir Khan, Rimsha Naaz Khursheed Ahmad, Awais Badruddoja, Momin Mashkoora Jabeen Sajid Akhtar, Saniya Bano Mohd Rafeeque, Ansari Abdul Muqueet Zaheer Ahmed, Farheena Shaheen Md Shafiullah, Momin Mohammad Armash Anjum Khawar, Waseem Akhtar Nabi Ahmed, Ansari Anshab Iftekhar
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4403441979