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Collagen fiber arrangement in the normal bladder lamina propria and their potential impact on the pathological substaging of bladder cancer stage T1.

Year: 2025

Type: article

Abstract: ). No difference was found in fiber perimeter or Feret diameter. Thus, we conclude that bladder collagen fibers are arranged in two distinct layers: a dense-ordered SLP and a loose disorder DLP. This indicates that the physical barrier to cancer cell invasion probably lies in the SLP, immediately underneath the urothelium. Once this barrier is breached, the looser and disorganized DLP poses no remarkable obstacle. Thus, we believe that histology-based subdivisions of stage T1 are expected to fail in providing clinically meaningful prognostic information.

Source: PubMed

DOI: 10.14670/hh-18-817

Authors: Ofer N Gofrit, Vladimir Yutkin, Mordechai Duvdevani, Guy Hidas, Tzahi Neuman

Institution: Hadassah Medical Center

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4403443034

FWCI:

Cites: 17

Cited by:

Related to: 10