Work

Synaptic dynamics linked to widespread elevation of H-reflex before peripheral denervation in amyotrophic lateral sclerosis

Year: 2024

Type: article

Abstract: Without significant evidence of peripheral denervation, H-reflex enhancement appears to be a widespread phenomenon, regardless of disease onset site. This increase is likely associated with a decrease in inhibitory control over presynaptic transmission of the synapse between muscle group Ia afferents and motoneurons. Although the link to exaggerated osteotendinous reflexes and spasticity implies a restricted role in identifying a pyramidal syndrome, its quantitative aspect positions the H-reflex as a valuable biomarker in clinical trials.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00144.2024

Authors: Sina Sangari, Alexandra Lackmy-Vallee, Arnaud Preuilh, Iseline Peyre, Pierre-François Pradat, Véronique Marchand-Pauvert