Work

No impact of a positive Chlamydia trachomatis serology on live-birth rate after intra-uterine insemination

Year: 2024

Type: article

Abstract: OBJECTIVE: To study the impact of a CT serology on intrauterine insemination (IUI) cumulative live-birth rate (cLBR) in women with documented bilateral tubal patency. DESIGN: Cohort study SUBJECTS: Infertile women with documented bilateral tubal patency and medical indication of IUI matched on the following criteria: woman's age, number of cycles completed and number of motile sperm inseminated (NMSI). EXPOSURE: This retrospective, observational and monocentric cohort study compared women with positive CT serology matched 1:1 to control women with negative CT serology. MAIN OUTCOME MEASURES: Cumulative LBR, rates of clinical pregnancy, spontaneous abortion, biochemical pregnancy. RESULTS: A total of 71 women in the CT positive group were matched to 71 women in the negative CT group, leading to compare 136 cycles per group. No statistically significant difference was observed between groups regarding the demographic and medical characteristics of couples. Cumulative LBR per woman was similar in both groups with 32.4% (n = 23) in the negative serology group Vs 25.4% (n = 18) in the positive CT group (NS). The rates of clinical pregnancy, spontaneous abortion, biochemical pregnancy were comparable between the two groups. CONCLUSION: In a population of infertile women with patent tubes, our study suggests that the serological status for CT has no impact on the IIU cLBR.

Source: Journal of Gynecology Obstetrics and Human Reproduction

DOI: 10.1016/j.jogoh.2024.102863

Authors: Virginie Trabaud, Laura Miquel, Cindy Faust, Julie Berbis, Odile Paulmyer-Lacroix, Blandine Courbiere