Work

Basolateral Mechanics Prevents Rigidity Transition in Epithelial Monolayers

Year: 2024

Type: article

Abstract: The mechanics of epithelial tissues, which is governed by forces generated in various cell regions, is often investigated using two-dimensional models that account for the apically positioned actomyosin structures but neglect basolateral mechanics. We employ a more detailed three-dimensional model to study how lateral surface tensions affect the structure and rigidity of such tissues. We find that cells are apicobasally asymmetric, with one side appearing more ordered than the other depending on target cell apical perimeter. In contrast to the 2D model, which predicts a rigidity transition at large target perimeters, tissues in the 3D model remain solidlike across all parameter space.

Source: Physical Review Letters

DOI: 10.1103/physrevlett.133.168401

Authors: Jan Rozman, Matej Krajnc, Primož Ziherl

Institutions: University of Oxford, Jožef Stefan Institute, Jožef Stefan International Postgraduate School, University of Ljubljana

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,750

Funders: Javna Agencija za Raziskovalno Dejavnost RS, Engineering and Physical Sciences Research Council