Arming oncolytic M1 virus with gasdermin E enhances antitumor efficacy in breast cancer
Year: 2024
Type: article
Abstract: Pyroptosis, driven by the N-terminal domain of gasdermin proteins (GSDM), promotes antitumor immunity by attracting lymphocytes to the tumor microenvironment (TME). However, current pyroptosis-inducing therapies like drug injections and phototherapy are limited to localized treatments, making them unsuitable for widespread or microscopic metastatic lesions. This study engineered oncolytic M1 viruses (rM1-mGSDME_FL and rM1-mGSDME_NT) to selectively deliver GSDME to tumor cells. These modified viruses enhanced tumor cell death in breast cancer models, suppressed tumor growth, extended survival in mice, and boosted immune cell infiltration, demonstrating significant anticancer potential through pyroptosis induction.
Source: iScience
Authors: Xiao-yu Chen, Ying Liu, Wen-bo Zhu, Shu-hao Li, Song Wei, Jing Cai, Yuan Lin, Jian-kai Liang, Guang-mei Yan, Li Guo, Cheng Hu
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,150
Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, Guangzhou Municipal Science and Technology Project, National Key Research and Development Program of China, National Key Research and Development Program of China Stem Cell and Translational Research, Basic and Applied Basic Research Foundation of Guangdong Province
OpenAlex ID: W4403457637