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Pediatric Cardiac Xenotransplantation and Expanded Access: Ethical Considerations

Year: 2024
Type: article
Abstract: Due to the current organ shortage waitlist, alternatives to allotransplantation are necessary. Xenotransplantation is currently being pursued as one such alternative in adults in need of kidney or heart transplantation. Cardiac xenotransplantation of genetically modified pig hearts has been conducted twice in adults under the United States Food and Drug Administration (FDA) expanded access criteria. Because of the shortage of transplantable hearts for children as well as the lack of mechanical circulatory support in this population, pediatric researchers are exploring FDA expanded access in high-risk neonates and infants who lack alternative options for survival. The adult cardiac xenotransplantation experience with expanded access can provide lessons and highlight nuances for researchers preparing pediatric application. This includes aspects of informed consent, biosurveillance, and protection of bystanders from potential xenozoonoses.
DOI: 10.1111/petr.14876
Authors: Daniel J. Hurst, Christopher Bobier, Anthony Merlocco, Luz A. Padilla, Daniel Rodger, David Cleveland, John D. Cleveland
Institutions: Central Michigan University, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, University of Alabama at Birmingham, UAB Medicine, University of London, London South Bank University, Birkbeck, University of London, Children's Hospital of Los Angeles
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,730
OpenAlex ID: W4403457787
FWCI: 2.666
Cites: 27
Cited by: 7
Related to: 10