Work

O ‐ p ‐Methoxyphenyl α‐Hydroxycarboxylic Acids as Versatile Hydroxyalkylation Agents for Photocatalysis

Year: 2024

Type: article

Abstract: Reliable radical precursors are crucial for photocatalytic processes. In particular, heteroatom-stabilized radicals have attracted considerable research interest in photocatalysis. Among them, α-amino radicals have received the most attention, while the research on α-hydroxy radicals is much less developed. Herein, we present O-PMP α-hydroxycarboxylic acids as novel precursors for the formation of oxygen-stabilized radicals. These radicals have been successfully used as building blocks in Pd-catalyzed allylation reactions, Ni-catalyzed arylation and alkenylation reactions, and Giese reactions. A subsequent deprotection step liberates the corresponding hydroxyalkylation products.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202403495

Authors: Christoph Nopper, Adrian Veith, Felix Himmelsbach, Luca Söhner, Bernhard Breit

Institution: University of Freiburg

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funder: Deutsche Forschungsgemeinschaft