Work

Ru(II)-Catalyzed C7 Trifluoromethylthiolation and Thioarylation of Indolines Using Bench-Stable Reagents

Year: 2024

Type: article

Abstract: )-H trifluoromethylthiolation and thioarylation of indolines using bench-stable reagents have been explored. Diversely substituted indolines were functionalized at C7 position in good to excellent yields. Radical quenching, deuterium labeling, KIE, and reaction order determination experiments were performed to support the proposed reaction pathway. Gram-scale synthesis and post-transformation of the synthesized products have also been carried out to demonstrate the applicability of the developed catalytic protocol.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.4c02058

Authors: Sumit, Sachin, Devesh Chandra, Upendra Sharma

Institutions: Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Academy of Scientific and Innovative Research

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board

Awards: G1828260565, G2568832333