Work

Ni-Catalyzed Asymmetric Reductive Arylation of α-Substituted Imides

Year: 2024

Type: article

Abstract: α-Aryl imides are common structural motifs in bioactive molecules and proteolysis-targeting chimeras designed for targeted protein degradation. An asymmetric Ni-catalyzed reductive cross-coupling of imide electrophiles and (hetero)aryl halides has been developed to synthesize enantioenriched α-arylglutarimides from simple starting materials. Judicious selection of electrophile pairs allows for coupling of both electron-rich and electron-deficient (hetero)aryl halides in good yields and enantioselectivities.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.4c09327

Authors: Li-Ming Chen, Chungkeun Shin, Travis J. DeLano, Alba Carretero-Cerdán, Golsa Gheibi, Sarah E. Reisman

Institutions: California Institute of Technology, KTH Royal Institute of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science Foundation, California Institute of Technology, Vetenskapsrådet, Division of Chemistry