Work

NK1 receptor blockade disrupts microtumor growth and aggregation in a three-dimensional murine breast cancer model

Year: 2024

Type: article

Abstract: recapitulates several essential aspects of the human cell line, rendering this murine line ideal to be used on immune-competent animals during in vivo studies. We have also found that both cell lines are susceptible to SP stimulation, and their proliferation is disrupted by NK1R antagonists (Aprepitant). In vivo studies are required to verify and refine these findings.

Source: Neuropeptides

DOI: 10.1016/j.npep.2024.102479

Authors: Silvia Gutierrez, M. Danilo Boada

Institutions: Atrium Health Wake Forest Baptist, Wake Forest University Health Sciences, Wake Forest University

Language: English

Topic: Cancer, Stress, Anesthesia, and Immune Response

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,280