Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases
Year: 2024
Type: review
Abstract: With the development of the technology to generate transgenic and knockout mice in the 1990s, investigators had a powerful tool to directly test the impact of altering a specific gene on a biological process or disease. Over the past three decades, investigators have used transgenic and knockout mouse models, which have altered expression of antioxidant genes, to test the role of oxidative stress/damage in aging and age-related diseases. In this comprehensive review, we describe the studies using transgenic and knockout mouse models to test the role of oxidative stress/damage in aging (longevity) and three age-related diseases, e.g., sarcopenia, cardiac aging, and Alzheimer's Disease. While longevity was consistently altered only by one transgenic and one knockout mouse model as predicted by the Oxidative Stress Theory of Aging, the incidence/progression of the three age-related diseases (especially Alzheimer's disease) were robustly impacted when the expression of various antioxidant genes was altered using transgenic and knockout mouse models.
Institutions: University of Oklahoma Health Sciences Center, University of Oklahoma, The University of Texas at San Antonio Health Science Center, South Texas Veterans Health Care System, Wake Forest University Health Sciences, Wake Forest University, Oklahoma Medical Research Foundation, Oklahoma City VA Health Care System
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,740
Awards: G2619364971, Membrane lipid peroxidation in pathogenesis of Alzheimer’s disease, G3255348759, G3495715663, The role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancer, G6286586753, G8269159621, San Antonio Nathan Shock Center of Excellence in the Biology of Aging, Wake Forest Claude D. Pepper OAIC - Renewal
OpenAlex ID: W4403466419