Work

Retinal Vascular Abnormality of Nonperfusion and Neovascularization in a Toddler With Neurofibromatosis Type 1

Year: 2024

Type: article

Abstract: PURPOSE: This report describes the case of a 13-month-old boy diagnosed with neurofibromatosis type 1, who presented with retinal vascular abnormalities including extensive nonperfusion and neovascularization. We also discuss the observed changes after photocoagulation treatment. METHODS: A 13-month-old boy presented to the Department of Ophthalmology at Peking University People's Hospital with a reduction in the width of the left palpebral fissure for the past 6 months. RESULTS: The boy exhibited more than six café-au-lait spots larger than 5 mm in diameter on his trunk and legs. Fundus examination of the left eye revealed significant neovascularization in the temporal periphery of the retina, with late leakage and nonperfusion also noted temporally in fluorescein angiography. Magnetic resonance imaging of the brain and orbits showed an enlarged left sphenoid body, a widened left cavernous sinus, and a large plexiform neurofibroma. Laser treatment was performed on the left eye. Five months later, the neovascularization was controlled. CONCLUSION: Careful fundus examinations and systemic reviews, especially fluorescein angiography, are essential. Timely laser treatment is crucial for controlling disease progression and preventing retinal detachment.

Source: Retinal Cases & Brief Reports

DOI: 10.1097/icb.0000000000001673

Authors: Qiaozhu Zeng, Yusheng Zhong, Tong Qian, Yong Cheng

Institutions: Peking University, Peking University People's Hospital

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Bethune Charitable Foundation