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Figure 3 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

Year: 2024
Type: other
Abstract: KD of TDO2 can increase IDO1 expression and activity in a compensatory manner. Stable genetic KD TDO2 (shTDO2) or scramble control (shSCR) in BT549 cells. A, Immunoblot of TDO2 and IDO1. B, Catabolite level shown in peak area (mean ± SEM) of formyl-KYN and KYN as measured by steady-state metabolomics in conditioned media from BT549 with shTDO2 or shSCR control. C, Activated AhR-regulated genes CYP1A1 and CYP1B1 with and without shTDO2. Data are displayed as mean ± SD with one-way ANOVA analysis. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
DOI: 10.1158/2767-9764.27241002
Authors: Li-Wei Kuo, Lyndsey S. Crump, Kathleen O’Neill, Michelle M. Williams, Jessica L. Christenson, Nicole S. Spoelstra, Micaela Kalani Roy, Amy Argabright, Julie A. Reisz, Angelo D’Alessandro, Meher P. Boorgula, Andrew Goodspeed, Mike Bickerdike, Benjamin G. Bitler, Jennifer K. Richer
Language: English
Open Access status: gold
OpenAlex ID: W4403468203
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