First episode depression during the perinatal period is associated with atopic diseases and persistently increased eosinophil and basophil levels
Year: 2024
Type: article
Abstract: PURPOSE: A previous diagnosis of depression is a strong predictor for perinatal depression, apart from other mental disorders, stress, and atopies. It is less clear which factors interfere if perinatal depression occurs as a first depression episode (fePND). METHODS: We examined the associations with atopies and related blood parameters using data of CoLaus|PsyCoLaus. RESULTS: Newly occurring depression during the perinatal period but not recurrent depression was associated with a lifetime diagnosis of allergies and asthma together with persistently increased levels of basophils and eosinophils. CONCLUSION: The results imply that immune function may play a relevant role in the risk of a fePND. If confirmed and detailed, these findings could serve as the basis for designing preliminary prevention strategies by observing eosinophil and basophil levels as well as symptoms of atopic diseases before/during pregnancy.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
Awards: Prospective associations of major depressive disorder with atherosclerotic cardiovascular disease, cognitive impairment and mortality in the community, Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study, Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study, Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population, Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey, Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study
OpenAlex ID: W4403470255