Work

Efficient modification of peroxydisulfate oxidation reactions of nitrogen-containing heterocycles 6-methyluracil and pyridine

Year: 2024

Type: article

Abstract: Nitrogen-containing heterocyclic compounds are widely used in pharmacology due to their pronounced biological activities and low toxicities. The introduction of a hydroxy function into uracil and pyridine molecules has led to compounds with antioxidant, anti-inflammatory, and immunomodulatory activity (3-hydroxy-6-methyl-2-ethylpyridine, 5-hydroxy-6-methyluracil, etc.). One of the successful methods for hydroxylation is peroxydisulfate oxidation. By modifying the Elbs reaction through catalysis and the introduction of additional oxidants, we have been able to significantly increase the yields of practically useful compounds.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.20.219

Authors: Alfiya Raisovna Gimadieva, Yuliya Zulkifovna Khazimullina, Aigiza Aidarovna Gilimkhanova, Akhat Gaziz:anovich Mustafin

Institutions: Russian Academy of Sciences, Ufa Institute of Chemistry

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Ministry of Science and Higher Education of the Russian Federation, Russian Academy of Sciences

Award: G2930191834