Extraction, pharmacological prediction and experimental verification of Coreopsis tinctoria flowers
Year: 2024
Type: article
Abstract: Coreopsis tinctoria (C. tinctoria) is a traditional plant with high medicinal value and edible value. It has the effect of invigorating spleen and stomach and has the potential to develop into flower tea. Therefore, the extraction process of C. tinctoria extract (CTA) was optimised by analytic hierarchy process (AHP) combined with orthogonal test, and its activity was predicted by network pharmacology and verified by experiments. The optimal extraction conditions: temperature of 80 °C, extraction period of 10 min, solid-liquid ratio of 1:70 and times 2. CTA had no gastrointestinal irritation and can significantly increase the faecal water content of mice, inhibit amylase activity, increase protease, xylanase and cellulase activity, increase the number of intestinal Lactobacillus and Bifidobacterium, reduce the number of Escherichia coli and Enterococcus. In summary, CTA can effectively improve the intestinal digestive enzyme activity and the number of probiotics and has the potential to treat gastrointestinal diseases.
Source: Natural Product Research
Authors: Xinyu Zhou, Aiping Xu, Xinmei Chen
Institution: Shandong University of Traditional Chinese Medicine
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4403472249