Sex Differences in Procedural Characteristics and Clinical Outcomes Among Patients Undergoing Bifurcation PCI
Year: 2024
Type: article
Abstract: BACKGROUND AND OBJECTIVES: The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men. METHODS: COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex. The primary outcome was 5-year target lesion failure (TLF), a composite of cardiac death, myocardial infarction, and target lesion revascularization. RESULTS: Women (n=635, 24%) were older, had hypertension and diabetes more often, and had smaller main vessel and side branch reference diameters than men. The pre- and post-PCI angiographic percentage diameter stenoses of the main vessel and side branch were comparable between women and men. There were no differences in procedural characteristics between the sexes. Women and men had a similar risk of TLF (6.3% vs. 7.1%, p=0.63) as well as its individual components and sex was not an independent predictor of TLF. This finding was consistent in the left main and 2 stenting subgroups. CONCLUSIONS: In patients undergoing bifurcation PCI, sex was not an independent predictor of adverse outcome. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03068494.
Source: Korean Circulation Journal
Authors: Hyun Jin Ahn, Francesco Bruno, Jeehoon Kang, Doyeon Hwang, Han-Mo Yang, Jung-Kyu Han, Leonardo De Luca, Ovidio de Filippo, Alessio Mattesini, Kyung Woo Park, Alessandra Truffa, Wojciech Wanha, Young Bin Song, Sebastiano Gili, Woo Jung Chun, Gerard Helft, Seung-Ho Hur, Bernardo Cortese, Seung Hwan Han, Javier Escaned, Alaide Chieffo, Ki Hong Choi, Guglielmo Gallone, Joon-Hyung Doh, Gaetano De Ferrari, Soon-Jun Hong, Giorgio Quadri, Chang-Wook Nam, Hyeon-Cheol Gwon, Hyo-Soo Kim, Fabrizio D’Ascenzo, Bon-Kwon Koo
Institutions: Seoul National University, Seoul National University Hospital, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Azienda Ospedaliera San Camillo-Forlanini, Azienda Ospedaliero-Universitaria Careggi, Azienda Sanitaria Locale di Asti, Medical University of Silesia, Samsung Medical Center, Sungkyunkwan University, Centro Cardiologico Monzino, Samsung Changwon Hospital, Université Pierre-et-Marie-Curie, Keimyung University Dongsan Medical Center, Keimyung University Dongsan Hospital, Gachon University Gil Medical Center, Universidad Complutense de Madrid, Hospital Clínico San Carlos, IRCCS Ospedale San Raffaele, Inje University Ilsan Paik Hospital, Korea University Anam Hospital, Ospedale di Rivoli
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1302329881, G4988901351, G5153421271
OpenAlex ID: W4403474861