GPX4 Promoter Hypermethylation Induced by Ischemia/Reperfusion Injury Regulates Hepatocytic Ferroptosis
Year: 2024
Type: article
Abstract: Background and Aims: Glutathione peroxidase 4 (GPX4) is a key factor in ferroptosis, which is involved in ischemia-reperfusion injury. However, little is known about its role in hepatic ischemia-reperfusion injury (HIRI). This study aimed to investigate the role of GPX4 methylation in ferroptosis during HIRI. Methods: promoter methylation, and global methylation levels were then assessed. Results: promoter methylation. Conclusions: promoter and elevated levels of global hepatic methylation are involved in the regulation of ferroptosis.
Authors: Chen Bai, Peilun Xiao, Yuting Chen, Fangfang Chu, Yue Jiao, Jiaqi Fan, Yuexia Zhang, Jiao Liu, Jiying Jiang, Shuna Yu
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403482895