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5/6 Nephrectomy impairs acute kaliuretic responses and predisposes to postprandial hyperkalemia

Year: 2024
Type: article
Abstract: Rats who underwent 5/6 nephrectomy demonstrate a reduced ability to excrete an acute K + load with the development of postprandial hyperkalemia. 5/6 Nephrectomy attenuates K + -induced natriuresis and impairs ENaC regulation despite intact NCC dephosphorylation and increased plasma aldosterone. This offers a potential explanation for why patients with chronic kidney disease are predisposed to postprandial hyperkalemia.
DOI: 10.1152/ajprenal.00195.2024
Authors: Kuang-Yu Wei, Martin Gritter, A. H. Jan Danser, Liffert Vogt, Martin H. de Borst, Joris I. Rotmans, Pedro Henrique Imenez Silva, Ewout J. Hoorn
Institutions: Tri-Service General Hospital, Erasmus MC, National Defense Medical Center, Erasmus University Rotterdam, Amsterdam University Medical Centers, University Medical Center Groningen, Leiden University Medical Center
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W4403485100
FWCI: 1.034
Cites: 43
Cited by: 4
Related to: 10