Work

Quantification and interpretation of nitric oxide-dependent cutaneous vasodilation during local heating

Year: 2024

Type: article

Abstract: Local heating protocols are commonly used in conjunction with intradermal microdialysis for assessing nitric oxide (NO)-dependent microvascular function in humans, but various methods used to quantify and describe NO-dependent vasodilation may impact data interpretation. We compared four approaches for quantifying NO-dependent cutaneous vasodilation during local heating at 39°C and 42°C. We identify discrepancies in calculated NO-dependent dilation responses that are dependent upon the mathematical approach and meaningfully impact data interpretation and reproducibility.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00558.2024

Authors: S. Tony Wolf, Gabrielle A. Dillon, Lacy M. Alexander, W. Larry Kenney, Anna E. Stanhewicz

Institutions: Pennsylvania State University, University of Georgia, University of Illinois Urbana-Champaign, University of Iowa

Language: English

Topic: Cardiovascular and exercise physiology

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green