Work

Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure

Year: 2024

Type: article

Abstract: Preexisting chronic kidney disease (CKD) predisposes experimental animals to augmented morbidity and mortality following cutaneous vesicant exposure. The mechanism underlying increased susceptibility to renal injury and associated morbidity involves the DNA damage-regulated p53 signaling pathway.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00139.2024

Authors: Ritesh Kumar Srivastava, Amie Mark Traylor, Suhail Muzaffar, Stephanie K. Esman, Reham H. Soliman, Jasim Khan, Phoebe Warren, Subhashini Bolisetty, James F. George, Anupam Agarwal, Mohammad Athar

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1056151686, G241834390, G3549958751, G3768497940, G4076626133, Blocking Arsenicals-induced Cutaneous Injury, Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury, Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury

OpenAlex ID: W4403485173

FWCI: 0.492

Cites: 75

Cited by: 2

Related to: 10