Work

Intravenous bolus injection of fentanyl triggers an immediate central and upper airway obstructive apnea via activating vagal sensory afferents

Year: 2024

Type: article

Abstract: Intravenous bolus injection of fentanyl triggers an immediate apnea, but the nature of apnea and relevant mechanisms remain unknown. Results in this study reveal that this fentanyl injection concurrently triggers an immediate central and upper airway obstructive apnea associated with chest wall rigidity via activating vagal sensory C-fibers.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00614.2024

Authors: Jianguo Zhuang, Xiuping Gao, Shan Shi, Fadi Xu

Institution: Lovelace Respiratory Research Institute

Language: English

Topic: Neuroscience of respiration and sleep

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute on Drug Abuse