Work

Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity

Year: 2024

Type: article

Abstract: Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00471j

Authors: Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava

Institutions: Indian Institute of Technology BHU, Banaras Hindu University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Banaras Hindu University, Indian Institute of Technology (BHU) Varanasi, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer

OpenAlex ID: W4403485344

FWCI: 1.67

Cites: 57

Cited by: 12

Related to: 10