Work

CSF1 mediating 3-hydroxyhexanoate in endometrial cancer: a Mendelian randomization study

Year: 2024

Type: article

Abstract: Introduction This study employed Mendelian randomization (MR) analysis to explore the causal relationship between 3-hydroxyhexanoate and uterine corpus endometrial carcinoma (UCEC), with a focus on the mediating role of colony stimulating factor (CSF1), a chemokine implicated in tumor progression. Results The analysis revealed a negative association between CSF1 and UCEC. Furthermore, the study identified a negative causal link between 3-hydroxyhexanoate and CSF1, suggesting that this metabolite may play a role in the pathogenesis of UCEC. Conclusions The findings suggest that 3-hydroxyhexanoate, through its association with CSF1, could influence the tumor micro-environment of cancer cells, potentially impacting cancer growth and progression.

Source: Archives of Medical Science

DOI: 10.5114/aoms/193392

Authors: Hu JIazhen, Fan Bozhen

Institutions: Shanghai University of Traditional Chinese Medicine, Central Hospital of Putuo District

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,078