Year: 2024
Type: article
Abstract: Despite the increasing use of copper in C−H functionalizations, the Cu‐catalyzed direct deuteration of C−H bonds remains a significant challenge due to its inherent low reactivity in inverse C−H bond reconstruction. In this paper, a novel strategy had been developed to reverse the copper‐catalyzed concerted metalation‐deprotonation process by inhibiting the unexpected disproportionation of Cu(II) to Cu(III). Picolinic acid was identified as a powerful ligand for facilitating this H/D exchange with D2O as deuterium source, and its inhibition activity was supported by preliminary control experiments and DFT studies.
Source: Chemistry - A European Journal
Authors: Yuhang Su, Zhi‐Jiang Jiang, Jiawei Han, Lujie Duan, Jian‐Fei Bai, Jia Chen, Zhanghua Gao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4403498242