Work

Formation of a Gemcitabine (dFdC) Acquired Resistant BT 549 Triple Negative Breast Cancer Cells

Year: 2024

Type: article

Abstract: Triple negative breast cancer (TNBC) is an aggressive variant of breast cancer (BC). TNBC can develop an acquired resistance after repeated exposure to anticancer drugs, which remains a major hurdle for the success of chemotherapy. The relapsed TNBC is commonly pan-resistant to various drugs with completely different resistant mechanisms. Gemcitabine BT549 cells were developed from white-type cells. The acquired resistant cells were observed to show high resistance to Gemcitabine, in addition they were also found to be cross resistant to 3 anticancer drugs (Vincristine, Doxorubicin and Paclitaxel). These acquired resistant cell can be used as models to further study the various mechanisms of resistance in cancer cells.

Source: World Journal of Biology Pharmacy and Health Sciences

DOI: 10.30574/wjbphs.2024.20.1.0744

Author: Tawari Erebi Patricia

Institution: Niger Delta University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4403500548