Work

Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria

Year: 2024

Type: article

Source: Cell

DOI: 10.1016/j.cell.2025.02.009

Authors: Yi Fu, Max Land, Tamar Kavlashvili, Ruobing Cui, Minsoo Kim, Emily DeBitetto, Toby Lieber, Keun Woo Ryu, Elim Choi, Ignas Masilionis, Rahul Saha, Meril Takizawa, Daphne Baker, Marco Tigano, Caleb A. Lareau, Ed Reznik, Roshan Sharma, Ronan Chaligne, Craig B. Thompson, Dana Pe’er, Agnel Sfeir

Institutions: Memorial Sloan Kettering Cancer Center, Thomas Jefferson University, Howard Hughes Medical Institute

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, Pew Charitable Trusts, Damon Runyon Cancer Research Foundation, G. Harold and Leila Y. Mathers Charitable Foundation, Memorial Sloan-Kettering Cancer Center, Edward Mallinckrodt, Jr. Foundation, National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of General Medical Sciences

Awards: G289723095, G4614148663, Cancer Center Support Grant, From mtDNA stress to cellular immunity: Triggers, Mechanisms and Effectors, Exploring the Role of Nitrogen Metabolism in Cancer, Investigating the impact and dynamic of mitochondrial common deletion in somatic cells

OpenAlex ID: W4408290631

FWCI: 4.714

Cites: 96

Cited by: 35

Related to: 10