Bortezomib Led to Remission of Immune Thrombocytopenic Purpura in a Patient with Smoldering Multiple Myeloma
Year: 2024
Type: article
Study design: Case Report
Abstract: A 79-year-old man with smoldering multiple myeloma (MM) developed sudden severe thrombocytopenia and active bleeding. Since anti-GPIIb/IIIa autoantibodies were detected on the platelet surface, thrombocytopenia due to an autoimmune etiology was diagnosed. Although neither steroids nor intravenous immunoglobulins provided improvement, bortezomib provided rapid normalization of the platelet counts with disappearance of the anti-GPIIb/IIIb autoantibodies. MM is rarely associated with immune thrombocytopenic purpura (ITP). Although the underlying pathogenesis of MM and ITP remains elusive, anti-myeloma drugs might be beneficial.
Source: Internal Medicine
Authors: Akane Yamano, Takayuki Ozawa, Takaya Endo, Midori Koike, Hisashi Kato, Tomoya Takahashi, Ayano Esaki, Hiroaki Masaie, Seiji Tadokoro, Satoru Kosugi, Toru Kida
Institutions: Toyonaka Municipal Hospital, The University of Osaka
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403507596