A simple method for assessing biological age and the rate of ageing of the cardiovascular system
Year: 2024
Type: article
Study design: Observational Study
Abstract: We developed a simple method for assessing the biological (functional) cardiovascular system age, based on our data on age-related changes in blood pressure, ECG, and HRV. We set ourselves the task of finding a simple non-invasive method for the integral assessment of the state of the cardiovascular system, which allows us to quantify the degree of age-related changes in this system. The essence of the method lies in the fact that the BA of the cardiovascular system is calculated according to the indicators of BP, QT and HRV. The study included 339 practically healthy people from 20 to 90 years (191 women and 148 men). The formula for calculating BA was obtained by multiple linear regression. The multiple correlation between biological age and chronological is high (r = 0.892; p <0.00001 for women and r = 0.897; p <0.00001 for men). The average absolute value of the BA calculation error is 5.19 ± 0.42 years for women and 5.14 ± 0.33 for men in this case. Thus, the formulas we obtained for calculating the BA are used in medical practice. The proposed model for determining BA can be used to identify individuals with accelerated cardiovascular ageing who require more advanced instrumental and laboratory examinations. Moreover, the developed method for assessing the rate of cardiovascular system ageing can be utilised as a rapid method for scientific research.
Source: Ageing & Longevity
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4403508323