Modular Access to Chiral 1,3‐Substituted Fragments via Nickel‐Catalyzed Arylboration Reaction†
Year: 2024
Type: article
Abstract: Comprehensive Summary Chiral 1,3‐substituted fragments are ubiquitous in pharmaceutical molecules and natural products, prompting the development of numerous methods to access these structures. Nonetheless, devising synthetic routes for complex chiral architectures in practical applications typically demands years of expertise. Herein, we developed a nickel‐catalyzed enantioselective migratory arylboration reaction of allylboronic esters using a chiral 1,2‐diamine ligand, yielding a range of chiral 1,3‐bis(boronates) with high enantioselectivity. The protocol is characterized by its use of commercially available substrates, mild reaction conditions, user‐friendly procedures, and a broad substrate compatibility. Moreover, we demonstrate the practicality and application potential of this reaction by synthesizing several key drug intermediates.
Source: Chinese Journal of Chemistry
Authors: Yang Bao, Tong Yao, Weiyu Kong, Yangyang Li, Ying Fu, Dong Wu, Guoyin Yin
Institutions: Wuhan University, Northeast Agricultural University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G2533774615
OpenAlex ID: W4403514546