Work

Comparative Immunohistochemical Analysis of Craniopharyngioma and Ameloblastoma: Insights into Odontogenic Differentiation

Year: 2024

Type: article

Abstract: BACKGROUND AND OBJECTIVES: Histopathological similarities between craniopharyngioma (CP) and ameloblastoma (AB) have long been recognized, particularly the shared features of palisading columnar epithelium and stellate reticulum-like areas. This study aimed to investigate potential odontogenic differentiation in CP akin to AB using immunohistochemical odontogenic markers. METHODS: We analyzed AMELX, ODAM, and CK19 expression in 44 cases (20 CP and 24 AB). RESULTS: While AMELX and ODAM showed diffuse strong positive expression in both tumors with no significant statistical differences, CK19 expression was notably higher in CP. CONCLUSION: The markers AMELX and ODAM associated with odontogenic differentiation exhibited similar profiles in both tumors due to shared similar embryological origins. Notably, CK19, a biomarker of odontogenic epithelium, showed even higher expression, suggesting distinct pathways. These findings offer insights into tumor biology and may aid in diagnostic and therapeutic approaches.

Source: Diagnostics

DOI: 10.3390/diagnostics14202315

Authors: Ban A. Salih, Bashar H. Abdullah

Institution: University of Baghdad

Language: English

Topic: Oral and Maxillofacial Pathology

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,955