Synthesis and antimicrobial activity of novel pyrido[2,3-d]pyrimidin-4(1H)-ones, and 2-pyrazoline derivatives
Year: 2024
Type: article
Abstract: The synthesis of thienyl indoyl chalcone produced a novel group of compounds bearing indole and thiophene moieties.The new series of substituted pyridines, 2-pyrazolines, and azepines were synthesized.2-Aminopyridines were produced by reacting chalcone with active methylene reagents.The chalcone were converted to pyrimidinones.These compounds served as the initial substrate for the synthesis 1thiocarbamoyl-2-pyrazoline.1-(4-oxo-5H-thiazolyl)-2-pyrazoline and 1-(4-phenylthiazolyl)-2-pyrazoline were synthesized by treating 1-thiocarbamoyl pyrazoline with chloroacetic acid or phenacyl bromide.The chalcone underwent a reaction with bifunctional agents resulting in the formation of azepines.The compounds were structurally determined with spectral data and they were tested for antimicrobial activity giving reasonable results.
Source: ARKIVOC
Authors: Ahmed Abdou O. Abeed, Mohamed Mohany, Sinisa Djurasevic, Salim S. Al-Rejaie, Talaat I. El-Emary
Institutions: King Saud University, University of Belgrade, Assiut University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funder: King Saud University
Award: G2781891264
OpenAlex ID: W4403534193