Work

Organocatalytic Strategy for a Formal 1,6-Conjugate Hydroxylation

Year: 2024

Type: article

Abstract: -propyl acrylate molecular platforms, a regio- and enantioselective sulfa-Michael reaction was achieved upon organocatalytic conditions, allowing the subsequent amidation, one-pot oxidation, and Mislow-Bravermann-Evans [2,3]-sigmatropic rearrangement along with a 1,3-chirality transfer, leading eventually to a formal asymmetric 1,6-hydroxylation sequence.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c03482

Authors: Sifeddine Mohamed Aouina, Anthony Lapray, Jean-Valère Naubron, Nicolas Vanthuyne, Vincent Levacher, Sylvain Oudeyer, Stéphane Perrio, Jean-François Brière

Institutions: Centre National de la Recherche Scientifique, Laboratoire COBRA, Université de Rouen Normandie, Institut National des Sciences Appliquées Rouen Normandie, Aix-Marseille Université, Centrale Méditerranée, École Nationale Supérieure d'Ingénieurs de Caen, Université de Caen Normandie

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Indian National Science Academy, Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Université de Rouen, Institut National des Sciences Appliquées Rouen, Institut Carnot Santé Animale, European Regional Development Fund

Awards: G1576599217, XLChem, Synthesizing our future, G2900821844, G4656594441, G5976147578, Synthèse Organique : des molécules au vivant

OpenAlex ID: W4403536185

FWCI: 0.282

Cites: 38

Cited by: 2

Related to: 10