Work

Sertraline-induced 5-HT dysregulation in mouse cardiomyocytes and the impact on calcium handling

Year: 2024

Type: article

Abstract: Sertraline exposure during development decreased the expression of critical genes in calcium regulation and lengthened periods in calcium oscillation in neonatal cardiomyocytes. Sertraline upregulated specific microRNAs that may modulate serotonin signaling in neonatal cardiac tissues, which corresponded with a decrease in the levels of the corresponding target mRNAs. Although the echocardiograms in our adult mice suggest a mild phenotype associated with sertraline exposure, these upregulated microRNAs (miRNAs) have been linked to adult cardiovascular disease and heart failure.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00692.2023

Authors: Yongjun Lu, Elizabeth Kenkel, Kathy Zimmerman, Robert M. Weiss, Robert D. Roghair, Sarah E. Haskell

Institutions: University of Iowa, University of Iowa Health Care, Bristol-Myers Squibb (United States), Iowa City VA Medical Center

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, NHLBI Division of Intramural Research