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174P Human adipose stem cells transfer their mitochondria to breast cancer patient derived organoids increasing drug resistance

Year: 2024

Type: article

Abstract: Mitochondrial transfer (MT) from mesenchymal stem cells showed to restore damaged cell function in inflammatory disease models. We showed that breast cancer (BC) cells acquire mitochondria from human adipose stem cells (hASCs) via tunneling nanotubes (TNTs), promoting multidrug resistance. Here we aimed at evaluating if MT occurs in patient-derived organoids (PDO) co-cultured with hASC.

Source: ESMO Open

Authors: M. Marigliano, M. Torsiello, C. Tufano, R. Concilio, A. Rehman, V. Tirino, M. La Noce, V. Del Vecchio, F. Papaccio

Institutions: University of Salerno, University of Campania "Luigi Vanvitelli"

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,730

OpenAlex ID: W4403537514

FWCI:

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Related to: 10