A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery

Year: 2024

Type: article

Abstract: The finding of new vesicular systems is a challenging process that depends on different factors such as the components used, the interactions between them or the dispersant media. Our objective was to develop a new vesicular delivery system formed by self-assembly of β-Sitosterol (Sit), Lauryl Glucoside (LGL) and Lauryl Glucose Carboxylate (LGC) molecules, all plant-based, biodegradable and biocompatible components. Nanovesicles (NVs) with different molar ratios of Sit, LGL and LGC were prepared using a single step method named DELOS, and characterized by dynamic light scattering, cryo-electron microscopy and small-angle X-ray scattering. Antioxidant compound α-tocopherol (TCP) was integrated in the NVs showing their potential to nanoformulate hydrophobic payloads. Finally, in vitro biocompatibility assays with reconstructed human epidermis and ex vivo skin retention studies using multiphoton microscopy and NVs labelled with Nile Red (NR) were carried out. As a result of this work, a new platform of NVs has been obtained by combining Sit, LGL and LGC, obtaining vesicular systems with tunable physicochemical properties in terms of size, surface charge and lamellarity, when the carbon chain of the alkyl polyglucoside was >12. The vesicles could efficiently integrate TCP, maintaining its antioxidant activity after loading, and showed biocompatibility with the skin improving the permeability of the poorly water-soluble molecule NR.

Source: Applied Materials Today

DOI: 10.1016/j.apmt.2024.102467

Authors: Marta Alcaina-Hernando, Ivana Malvacio, Ilaria Ferraboschi, Cristián Huck-Iriart, Annalisa Bianchera, Santi Sala, Jan Skov Pedersen, Lidia Ferrer-Tasies, Silvia Pescina, Cristina Sissa, Nora Ventosa, Alba Córdoba

Institutions: Institut de Ciència de Materials de Barcelona, University of Parma, ALBA Synchrotron (Spain), Aarhus University, Instituto de Salud Carlos III, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro de Investigación Biomédica en Red

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,840

Funders: Dipartimenti di Eccellenza, European Commission, Generalitat de Catalunya, Ministero dell’Istruzione, dell’Università e della Ricerca, Ministerio de Ciencia e Innovación, Agència per a la Competitivitat de l’Empresa, Universitat Autònoma de Barcelona, Horizon 2020 Framework Programme, Agència de Gestió d'Ajuts Universitaris i de Recerca, Horizon 2020, H2020 Marie Skłodowska-Curie Actions

OpenAlex ID: W4403537656